Sunday, February 27, 2011

Why Dogs Are Better Than Doctors

Over the past ten years, myriad groundbreaking and progressive cancer treatments have been implemented in oncology departments everywhere. Whether the treatment involves some sort of chemotherapy, radiation or positive psychological therapy, more and more advances are being made to make sure cancer is detected and attacked as early as possible.

What would at first appear to be completely unrelated to this is that dogs have a fantastic sense of smell [up to one third of a dog's brain is devoted solely to olfactory detection]. In light of this, recent studies have implied that dogs' senses of smell are good enough to sniff out cancer.

This may sound wild and wacky [I admit I had to reread the abstract three times just to make sure I was reading what I thought I was reading], but it's absolutely true. A recent article published in GUT posited that labrador retrievers that smelled the exhaled breath and watery stool samples of colorectal cancer (CRC) patients were able to identify even early cases of CRC extremely accurately.

In the study, Sonoda et al. exposed dogs highly trained in scent detection to the breath and stool samples of both CRC patients and normal, healthy subjects. For exhaled breath, the labradors had a detection sensitivity [compared to regular colonoscopy] of 0.91 and a specificity of 0.99. The sensitivity of the watery stool samples was even higher--0.97, and the specificity was 0.99. These measures were not confounded with inflammatory disease, benign colorectal disease or even current smoking behaviors.

Just one more reason to love animals! [if you need yet another, check out this cute and fuzzy video that has absolutely nothing to do with science]

Full pdf article can be found here.

Thursday, February 24, 2011


Headaches...and Accents?

Headaches are the worst. Right when you have piles of work to do, your head is just throbbing with this annoying pain. At this point, you usually decide to stop whatever you’re doing and just take a nap. But have you ever imagined waking up with a foreign accent? This is exactly what happened to a woman in New Castle, U.K who got up one morning with a Jamaican accent (which actually sometimes altered with a Slovenian accent), and a Michigan woman who developed an English accent after a severe migraine. Across the world, individuals who have gone through significant head trauma have developed of all sorts of new accents such as Chinese, Hungarian, French, and British. So what do headaches have to do with foreign accents? It is a condition called Foreign Accent Syndrome. Foreign Accent Syndrome is cause by severe brain injury. It is commonly a consequence of stroke, but can also occur after severe migraines. Significant head trauma can damage the regions of the brain responsible for linguistic functions, and can alter aspects of speech production such as intonation, rhythm, tone, and timing. Thus, an individual still has the same knowledge of the language but the way in which it is produced is changed in a fundamental way. To read more about FAS check this out: http://healthland.time.com/2010/09/16/a-severe-migraine-could-give-you-a-new-accent/

Monday, February 21, 2011

Let's Get Physical?

If you're at all health conscious, you've probably been to a gym at least once. Sure, you may have tried the elliptical, stationary bike, treadmill, stair master and maybe even the weight room, but did you remember to exercise the most important organ in your body?

Your buns aren't the only thing that need a little work every once in awhile; the brain should also be exercised regularly. While it's true that we use our brains constantly, consciously focusing on using it in a certain way can yield extremely beneficial results [though it likely won't make your head any larger...in the literal sense, anyway].

Cognitive Critique, a fellow neuroscience blog, recently posted a list of three brain exercises anyone can do anywhere and at any time. No gym necessary! The exercises, titled "Lazy Eights," "Cross Crawl" and "Positive Points," involve the integration of hand motions with conscious focus and last only a few minutes each. The list can be found here.

Alright, so I'll be the first to admit it sounds a little silly. However, with regular practice, these exercises may increase your attention span and improve your cognitive ability. So put on that spandex onesie [or not] and get to work; your brain will be spring break-ready in no time!

The Life of a "Memory Athlete"

Think you're good at memorizing facts and information for exams? When someone tells you a phone number, can you simply remember it or do you have to immediately whip out your phone and write it down? Can you memorize an entire deck of shuffled playing cards in their exact order in less than 22 seconds? If you think you're particluarly good (or bad!) at comiting information to memory, check these people out. Maybe you can learn a few tricks for that next midterm...

"Some disciplines, called speed events, test how much the contestants can memorize in five minutes (record: 480 digits)"


Afterwards, you can test yourself with this mind game to see if it worked!

Upcoming Events

The Penn Bioethics Society and the Scattergood Program for the Applied Ethics of Behavioral Health
presents
Mental Health Ethics Movie Series
Each night there will be a speaker followed by a screening of a movie:
2/23, 4:30:
John Moreno: One Flew Over the Cuckoo's Nest
3/23, 5:30:
Lance Wahlert: Marnie
4/21 6:30:
Arthur Caplan: Titicut Follies
All movies shown at 3401 Market St, 331
Food will be served!
Future of Drugs in Society
A Panel discussion with Dr. Jason Karlawish of Geriatric and Internal Medicine and Dr. Martha Farah of Neuroscience and Society
2/24, 6-7:30
4th floor college hall
This panel aims to discuss the changing role of perscription drugs in society- everything from chronic drug therapies for age-associated diseases to adderal abuse as a form of mental enhancement

Tuesday, February 15, 2011

The Social Network

How many friends do you have on Facebook? What about the amount of people that you text/ call on a regular basis? Human beings today (our generation in particular) live in a society of unprecedented social connectivity; We are able to instantly communicate with one another, and to keep in touch with old friends that we might have previously lost touch with. Overall, technology has had a significant impact on the size and maintenance of our individual social networks over the course of the past few decades, and a new study shows that a particular region of the brain is keeping up.

Kevin C. Bickart and his colleagues at the Boston University School of Medicine released a study that indicated that the size of the amygdala, a sub-cortical structure in the limbic area of the brain, has been shown to be highly correlated with the size and complexity of one’s social network. After reading this, my first thought was, “How have the social network-expanding websites and gadgets of the technological age (i.e. Facebook, Twitter, smartphones, etc.) already begun to alter our brain morphology?!” Afterall, evolving adaptations via natural selection takes millions of years. However, one will notice that social networks, in fact, have been around for millions of years. For many animals, especially primates, living with others in groups proved a significant adaptive advantage to survival and reproduction. Yet, with cooperation comes competition, and so it became favorable for one to be capable of differentiating between ally and enemy, distinguishing teammate from competitor. It also became beneficial for individuals to possess the capability of understanding who in the community holds dominant roles, and acting accordingly so to not unreasonably risk injury or death.

In accordance with the evolutionary theory of animal behavior, this form of social awareness evolved into what it is in humans today. The Social Brain Hypothesis suggests that “living in larger, more complex social groups selected for larger brain regions with a greater capacity for performing relevant computations and economic decisions.” The various functions that the amygdala is responsible for include emotional learning, fear conditioning, and affect/ empathy formation, all characteristics mandatory for successful navigation through one’s day-to-day social environment. So logically, it makes sense that a larger amygdala (with increased function), might account for a larger social network. Evolutionary theory would suggest that the amygdala has evolved this way in primates over time, specifically tailored through the generations until finally it has become able to deal with the complexities of the intricate social web that is apparent in human society today. In doing so, the larger amygdala allows us to more efficiently recognize and address different socio-emotional cues from those in our environment, furthermore providing us with sufficient information to make the best possible decisions in a world of co-existing social cooperation and competition.

The study suggests further looking into a causal relationship between amygdala size, and social network size and complexity: does being born with larger amygdala provide one with an advantage in maintaining a more vast social network? Conversely, does the amygdala grow as one increases the size/complexity of his social network? All in all, it makes one wonder...what does Mark Zuckerberg’s amygdala look like? To read more...click here.

Sunday, February 13, 2011

Jack & Diane & Your Brain

Valentine's Day is tomorrow, y'all. For those of you with significant others, spending exorbitant amounts of money on a mediocre steak and boxed red wine may be in your near future. The rest of us [myself included], however, have slaps in the face from every Hallmark-worthy couple and vomit-inducing bouquet of roses to endure.

Perhaps I'm a little cynical, but can you blame me? Love, a concept so abstract, so complicated, so devoid of scientific foundations, is hard to understand, let alone appreciate as a single college student majoring in neuroscience.

But wait! There's hope.

Acevedo, Aron, Fisher et al. recently published an article in Social Cognitive and Affective Neuroscience titled 'Neural Correlates of Long-term Intense Romantic Love' that investigates where and how love is expressed in the brain.

[Note: the image above is a painting by Greg Dunn titled "Hippocampus" and can be found on his website, here.]

They studied married subjects using fMRI experiments to determine where the brain is activated while the subjects were thinking about their spouses. To control for confounding variables, subjects were also exposed to a long-term acquaintance, a close friend and a stranger while undergoing the fMRI procedures.

The authors observed that areas of the dopamine reward and basal ganglia systems were activated during the subjects' exposure to their spouses. Additionally, the hypothalamus and posterior hippocampus were found to be associated with sexual frequency. Lastly, the study discovered that the caudate, the septum/fornix, the posterior cingulate and the posterior hippocampus were correlated with obsession [creepy].

Alright, so you probably don't have a spare fMRI laying around your house to analyze your girlfriend or boyfriend while he/she watches you. However, these findings add to the growing resources citing that love does, in fact, have a biological basis.

So in the end, I guess love is like a box of chocolates: you never know what you're gonna' get [unless you apply and receive funding from the NIH, perform extensive neuroimaging experiments, analyze the data and most likely lose your significant other in the process]. Happy Valentine's Day!

Thursday, February 10, 2011

**Penn Speaks for Autism**

Do you have a story to share about Autism? Would you like to submit a personal story about your experiences with Autism? Are you interested in current Autism research and would like to write about ongoing research?

Penn Speaks for Autism is looking to collect personal accounts of experiences and research updates for our newsletter that will be coming out in the next month. Please e-mail Amy at weissamy@sas.upenn.edu by Wednesday, Feb. 16 with an idea if you would like to share.